April 15, 2008
By Kimberly Rinker
Over years the indiscriminate use of steroids in racehorses worldwide has been the subject of speculation and controversy—overshadowed by the constant attention given to professional human athletes in the media on this subject. It is well known that most elite sport participants (football, baseball, basketball, Olympic contenders, etc.) have at their disposal a wide array of supplements, both legal and illegal.
Performance enhancing drugs such as steroids and human growth hormones have been outlawed in all professional human sports in the United States, but are still allowed in horse racing. Trainers use steroids and hormones as a matter of course to prolong a racehorse’s career, and the question remains, what effects do these drugs have on the horse’s career after racing, and what effect does this have—if any—on the betting public?
Medication in itself is often an issue of controversy among horsemen and racetrack management and often is perceived as “the evil or dirty side of horse racing” to some fans. Steroids are legal medications that are used without regulations. Some horsemen like them, some do not, while others in the business consider them unethical forms of treatment.
Ultimately, steroids can have both a positive and negative effect, on one hand helping to improve a horse’s health through a stimulated appetite, increased weight gain, and the healing of injured joints, and on the other hand, causing temporary reproductive problems in the breeding shed for both sexes.
As well, rumors abound as to whether some breeders and consignors use steroids to muscle-up yearlings for sale at public auction. Some trainers will openly admit to putting their youngsters on a steroid program throughout their 2 and 3-year-old seasons. Questions continue to be asked, but in the long run, what happens to the horse who is on steroids long-term?
The History
Steroids were first developed in the early 1930s, when scientists discovered that they could increase the muscle mass of laboratory animals with their use. Later that decade scientists perfected steroids to treat hypogonadism, a condition which does not allow the body to produce a sufficient amount of testosterone for normal growth and sexual function on its own.
By World War II Nazi doctors were administering steroids to soldiers in order to toughen them up for combat. Later, it was found that soldiers returning from combat who were suffering from malnutrition and anemia revived much more quickly when given steroids. After the war, steroids could be found in many hospitals in both Europe and North America, and their use quickly spilled over into the sporting world. Testosterone was one the first to be used by athletes of the Eastern block nations in the early 1950s.
Dr. John Ziegler, MD was one of the first to begin developing steroids for use in athletes in this country, particularly for football players, as the health dangers were first thought to be minimal. By the mid-1960s steroid use in football players was commonplace, and soon, the use spilled over into the racehorse and dog racing industry, and in the meat production industry. In 1974 the problem among human athletes had become so pronounced that the International Olympic Committee (IOC) prohibited the use of steroids in Olympic competition and training. As a result, the illegal trade for steroids followed shortly and the rest, as they say, is history.
Today there are more than 100 different types of steroids available in North America to be used via a prescription. Steroids obtained illegally are typically developed on the Black Market and then smuggled into this country.
In the Athens Olympic games, a high number of horses tested positive for prohibited substances—and many were steroids. The International Equestrian Federation (FEI) had announced that they would have to “revisit our entire medication policy,” as a result of the apparent abuse of prohibited substances at those Olympic games.
What They Are & What They Do
Steroids are produced legally for medical use on nearly every continent around the globe. They are used to regulate the endocrine system—the part of the body that controls cellular activity throughout an animal’s system. The endocrine system is what produces hormones. These hormones go directly into the bloodstream and target specific problem areas.
Corticosteroids
Corticosteroids are released by the adrenal glands, which include an inner (medulla) and outer (cortex) portion. Corticosteroids help to regulate protein and carbohydrate metabolism and produce several steroidial hormones, as well as playing a critical role in the body’s mineral and water balance. As well, some of these corticosteroids produce properties helpful in the reduction of pain and inflammation as a result of stress related injuries. Joint lameness is the leading cause of pain in racehorses.
The intra-articular use of corticosteroids first began in 1955 for the treatment of joint disorders in the equine athlete. This group of steroids includes dexamethasone, prednisone and cortisone. Often, prolonged use of corticosteroids results in a tissue-wasting effect, which is then relieved by anabolic therapy.
One of the first corticosteroids used was cortisol, produced naturally in the adrenal glands of all animals. The adrenals are a pair of small glands lying in front of each kidney, and each produces three types of steroids: mineral-corticoids (responsible for maintaining the levels of sodium & potassium in the body), sex steroids (anabolic steroids) and Glucocorticoids (responsible for glucose metabolism).
Anabolic Steroids (anabolic-androgenic steroids)
These are “male sex hormone” steroids, similar to the male sex hormone testosterone, and have a pronounced stimulatory effect on constructive metabolism. They are used to promote muscle growth and can improve the condition of anemic animals and can positively affect performance and weight gain, and are often used as an appetite stimulant. In humans these steroids are used on routinely on chemotherapy patients.
Applications in Racehorses
Studies have proven that horses treated over an extended period will grow dependent upon anabolic steroids for functions that their bodies would perform were they not treated with the drug. When the administration of steroids is suddenly stopped, the horse’s endocrine system is not prepared to handle the sudden loss of treatment.
For example, a horse treated with ACTH for a lengthy period will have the natural production of ACTH provided by the pituitary gland decrease and eventually stop. This in turn causes the adrenal cortex gland to shrink and stop functioning, which also causes natural steroid production to halt as well.
Overall, the horse’s system is completely confused by the overabundance of artificially administered substances to the body, and the horse will often develop a kind of addiction to the steroids. Other side effects on the endocrine system include hyperglycemia, osteoporosis, increased coagulation of the blood stream, depression, electrolyte imbalance and death.
Certainly, these same side effects do not apply to corticosteroids that are used to inject joints in racehorses. Dr. Scott Hopper, DVM, of Lexington’s Rood & Riddle Equine Clinic says that he utilizes various steroids routinely on horses that he treats, and that the type of steroid injected into the joint depends on the joint.
“For low motion joints such as pasterns, I’ll use depo,” Hopper said. “For high motion joints, such as upper hocks, I’ll use a combination of vetalog, predef and a hyaluronic acid. Using steroids inarticulately is common practice and for some racehorses, this is what keeps them in action. We also make sure that the horses we service are good candidates for whatever type of medication we’re going to inject.”
Hopper said the type of clients he services are very different from the typical racetrack veterinarian, whose trainers often routinely use steroids on raceway horse’s joints week-in and week-out for maintenance.
“With corticosteroids, my experience has shown that these don’t produce overnight results,” Hopper noted. “It takes some time for them to work, and to get the full benefit of them. It doesn’t happen overnight. Those folks who are injecting the same joint week after week are, in my opinion, kind of throwing their money away. At our practice we are looking to get the best response possible, and therefore I always tell my clients that time is their best ally.
“Of course there are the cases for overnight horses where, if a vet is able to isolate a problem joint, that they would then inject that joint on a routine basis. However, I feel that a favorable response to that injection would be to see that the treatment last for 60 days at least.”
Dr. Tony Petrowitz, DVM, a graduate of Iowa State and a practitioner at Chicago-area racetracks, says he favors using a combination of ingredients on his client’s horses.
“Most often, we mix depo, dex (dexamethasone), Vetalog or Predef along with a hyaluronic acid for a joint injection,” Petrowitz noted. “This combination will last a little longer and is good at taking inflamation out of a joint. It’s a little kinder treatment than straight depo.”
“In contrast, Betamethasone is a little quicker acting medication, but we don’t use it as much because it’s much costlier than the other injectable corticosteroids,” Petrowitz added.
In the mid-1990s Dr. Dave Frisbie, a 1992 graduate of the University of Wisconsin, studied the effects of various types of steroids used for intra-articular injections. His project on Vetalog and Depo-Medrol found that sample horses who were administered these corticosteroids in a normal joint received effects on a remote joints containing chip fractures. Further, the study suggested that detrimental effects from the use of corticosteroids in joints may have been overstated.
Chicago-based conditioner Dave McCaffrey says he doesn’t believe that steroid use is the end-all to success when it comes to training pacers and trotters.
“Using steroids is a horse to horse decision, and ultimately, it’s a steroid to steroid decision,” Dave noted. “If I were to claim a horse that has won two or three races in a row it could be hard to tell if that horse had been given steroids, although certain steroids tend to give themselves away. Some trainers call it “roid rage.” For instance, if you see a gelding that’s acting crazy and trying to breed everything in sight, then you can be pretty sure that he’s been given a steroid of some type.
“Just like baseball players who are floundering in the minor leagues, you can’t take a horse that’s doing poorly and expect to improve a horse five seconds by using a steroid on him,” Dave added. “Of course you hear that certain trainers are using this or that steroid on everything—especially if they’re winning a lot of races. The ultimate 64,000 question is: ‘do steroids help horses to go faster?’ The side effects of steroids can make a horse go faster, but the drug by itself does not. In other words, if you’re stronger, with more muscle mass than the next fellow, it stands to reason that you’ll perform better.”
Robin Schadt, trainer of Odds On Racing of Crete, Illinois agrees with McCaffrey.
“Steroids are fine when they aren’t abused,” Robin said. “It’s another legal tool that we, as trainers, have at our disposal. It benefits some horses when used diligently and responsibly. For instance, Winstrol definitely helps certain finicky female horses and sulky make horses. Sometimes we’ll use Regimate and chorionic on mares to keep them from cycling.”
Dirk Simpson, a noted Illinois colt trainer based at the State Fairgrounds in Springfield, says he uses steroids on some of his youngsters, but that cost limits his use of the medication.
“Four to six out of ten of my horses will be on Winstrol,” Dirk noted. “It adds muscle mass and helps to bulk them up. The dosage is low and I do it in the spring for six to eight weeks and whenever I think they need it. The economics of this business just doesn’t allow for much more of it that that in Illinois.”
Balmoral-based conditioner Jim Eaton has other ideas.
“I never really thought that steroids helped a horse that much,” Eaton said. “I’ll use Winstrol because it helps a horse that is skinny to put on weight through being an appetite stimulant, and will tend to make fillies a little more aggressive. I’ve never given any steroids to 2-year-olds—I just don’t believe it’s necessary.”
Effects on the Breeding Industry
Thomas Tobin, M.V.B, Ph.d, is a reowned toxicologist and author of Drugs and the Performance Horse—a familiar book found on many horsemen’s shelves. Tobin stressed that giving anabolic steroids to young horses could improve their growth and muscular frame that would put undo stress on immature bones and tendons in the racehorse.
Breeder and veterinarian Diana Wilson, of Wilson Standardbreds, works on 80+ broodmares at her east-central Illinois breeding facility.
“It’s obvious, when you palpate mares, to tell the ones that have been on a ‘healthy’ steroid program,” Wilson, DVM said. “Most of them have tiny ovaries. The mares who have been given a lot of steroids and hormones will tease other mares and often times start mounting them. This will go on for a few months until the drugs pass out of their systems.”
Stallions who have been treated with steroids will often experience a significant loss of testicular size. Dr. Terry Blanchard, a recognized authority on stallion fertility who practices at the Hill N Dale thoroughbred farm in Lexington, Kentucky, says that unless the history of a stallion is known, it can be hard to pinpoint steroids as the problem with the horse’s testicular size.
“As a vet of a breeding farm, if we’re looking at a stallion prospect, it’s important for us to know his medical history,” Blanchard said. “If we know that he’s been treated regularly with anabolic steroids, then the odds are in that stallion’s favor as a prospect.”
“It’s important to note, however, that any athlete that is fit and is stressed in athletic competition on a consistent basis will most likely see a reduction in testicular size. He doesn’t necessarily need to have been given steroids,” he added. “For example, in the thoroughbred industry, most of our bigger races, like the Breeders Cup, are in the fall. If we’re planning on breeding a stallion in February following the end of their racing career in the fall, it’s pretty typical that any steroids he’s been given will have washed out of his system by that time.”
“The trouble you run into is with the insurance companies,” Blanchard said. “The insurance companies are reluctant to insure stallions with diminished testicular size—the theory being that ‘size determines the output.’ Often, a stallion’s testicles will return to their normal size once the steroids have washed out of their system. Also, some stallions with average sized testicles will produce little sperm, while those with smaller testicles will produce a great amount of sperm. However, if you give steroids for enough time, the sperm production does decrease. But the research has suggested that most of those effects are reversible.”
Blanchard says that research on yearlings in Sweden has shown that there were no lasting effects on these youngsters treated with steroids. Likewise, research at Colorado State and the University of Missouri revealed that testicular size returned to normal after a few months, and in some cases only a matter of weeks when steroids were no longer administered.
Common Anabolic Steroids
ACTH (Adreno-corticotrophic Hormone)
ACTH stimulates the production of cortical hormones in the adrenal cortex, causing them to produce hormones at an increased rate.
Androstenedione
Pro-hormone drug that gives a short-term increase in testosterone; producing immense testosterone effects. This was one of the first hormones to become popular in the human sports industry.
Beta-blockers
Lowers blood pressure by slowing the output of blood from the heart. Popular Beta-blockers include Avapro and Coreg.
Boldenone (Equipoise)
Commonly used on racehorses and first used in the 1970s. Studies have shown that mares
raced on Equipoise for a long period of time had problems once when they became broodmares, with many not getting in foal their first year. Conversely, geldings and colts that raced on this drug for a long period of time were known to develop arthritic problems such as osselets quicker than horses on which no steroids were used.
Depo-Testosterone (Testosterone Cypionate)
Depo-testosterone is used to replace testosterone levels in horses who have been gelded. It belongs to the group of medications known as Androgens (male hormones).
EPO (Erythropoietin)
A hormonal substance formed in the kidney that stimulates red blood cell growth, increasing the body’s ability to store and use oxygen. Genetically engineered, it is known to increase endurance in horses and humans.
HGH (Human Growth Hormone)
Occurs naturally in the body. It is also genetically engineered and used to treat children with dwarfism, and often used to increase muscle mass in both horses and humans.
Nandrolone (Deca-Durabolin)
Produces rapid muscle and bone growth, and for a long time has been the drug of choice among human bodybuilders and strength athletes of its quick response. It also decreases body-fat levels and will help aid in joint problems (arthritis). It is also popular because it tends to have less side effects (like increased body hair growth) than other anabolic steroids. Moderate administration of Deca-durabolin has been show to lower estrogen levels.
Stanozolol (Winstrol-V)
Stanozolol is a synthetic derivative of the male hormone testosterone. This particular steroid has a pronounced anabolic effect with fewer masculinizing side effects than other synthetic testosterones. Stanozolol increases the retention of nitrogen and minerals and reverses tissue-depleting processes. Its anabolic effect include an improvement in appetite, weight gain and a general overall well-being.
Common Corticosteroids Steroids
Betamethasone (Betasone)
Betamethasone is used to treat many different conditions in humans & animals. It is used to treat endocrine (hormonal) disorders when the body does not produce enough of its own steroids. It is also used to treat many immune and allergic disorders, such as arthritis, lupus, psoriasis, asthma, and Crohn’s disease in people. It is used in horses primarily for joint injections and is a quick acting, anti-inflammatory. Most often it is used for acute and traumatic lameness in the carpal and fetlock joints.
Depo-Medrol, Cortisate-20 (Methylated Prednisolone)
Depo-Medrol is a popular anti-inflammatory glucocortico-steroid used primarily for intramuscular and intra-articular (joint) injections. It is useful in treating overall arthritis and trauma to joints.
Dexamethasone (Azium)
Azium is a powdered form of dexamethasone, which has shown through clinical research to have many potent hormonal and metabolic effects greater than either prednisolone or cortisone.
Predef 2X
As the only corticosteroid approved by the FDA for use in dairy cattle, Predef 2X is typically mixed with a hyaluronic acid for intra-articular joint injections.
Solu-Delta-Cortef
Useful in alleviating lameness from arthritic conditions. Treats bursitis, carpitis, tendinitis and myositis.
Vetalog (Triamcinolone)
Vetalog is a synthetic, highly potent glucocorticoid, anti-inflammatory and antihistaminic.
For More Information on this subject:
Forbes, G. 1985 The Effect of Anabolic Steroids on Lean Body Mass
Brander, G.C., D.M. Pugh. 1977. Veterinary Applied Pharmacology & Therapeutic
Third Edition.